Webin copper transport is currently lacking. According to computer algorithm analyses, Ctr family members contain three mem-brane-spanning domains, within which most of protein se-quence similarity lies. Biochemical and microscopy experi-ments in yeast and human cells have suggested that Ctr family members are integral membrane proteins that ... WebFeb 8, 2002 · This is the first report on the biochemical characterization of the human copper transporter hCtr1, which is important for understanding mechanisms for mammalian copper transport at the plasma membrane. The trace metal copper is an essential cofactor for a number of biological processes including mitochondrial oxidative …
Human copper transporter 2 is localized in late endosomes and …
WebOct 1, 2024 · The moss Physcomitrium (Physcomitrella) patens is a bryophyte that provides genetic information about the adaptation to the life on land by early Embryophytes and is a reference organism for comparative evolutionary studies in plants. Copper is an essential micronutrient for every living organism, its transport across the plasma membrane is … WebMar 1, 2004 · A different class of transporter known as the SLC31 or Ctr family of proteins mediates cellular copper uptake. These high-affinity copper transporters exist in all … diamond studs for guys
Structural and Functional Diversity Among the Members of CTR…
WebFigure 1. Bioinformatic analysis identifies C. thermophilum copper transporters. A, model showing a homotrimeric Ctr1/Ctr3 family protein complex with key Cys and Met residues involved in Cu + transport connected with a dashed red circle and key Gly residues involved in trimer stability via transmembrane helical packing highlighted with a red box. … WebSolute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the basis for the ... WebNov 1, 2006 · CTR1 belongs to the CTR (or SLC31A) family that includes CTR1/2 and P-type copper transporting ATPases (ATP7A and B). It is a 23-kDa channel-like transporter which has a unique pore for the transport of copper and three trans-membranes domains that oligomerize to form a functional trimer [85]. ciscycling