Hif2a抑制剂
WebNordihydroguaiaretic acid (NDGA) 是一种具有细胞毒性的 insulin-like growth factor-I receptor (IGF-1R)/HER2 的抑制剂，可诱导细胞凋亡。. Nordihydroguaiaretic acid (NDGA) 可抑制 p300 并激活自噬。. Nordihydroguaiaretic acid (NDGA) 可保护细胞免于铁死亡。. NT157, 一种选择性 IRS-1/2 抑制剂，具有在 ...
Hif2a抑制剂
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Web5 de jun. de 2015 · We sought to establish if the observed increase in HIF2A mRNA expression in hypoxic neuroblastoma cells was a general tumor cell phenomenon. In glioblastoma, another neural cell-derived tumor with an apparent dependency on HIF-2α [5], [16], [17], it has been suggested that HIF2A transcription is induced at hypoxia, in … Web20 de jun. de 2024 · HIF-1α (HIF1A) is known to be associated with the upregulation of glycolytic genes such as phosphoglycerate kinase ( PGK) and lactate dehydrogenase A ( LDHA ), both of which function to...
WebThe genes coding for hemoglobin, beta globin and alpha globin (high-oxygen-affinity hemoglobin variants), hemoglobin-stabilization proteins (2,3 bisphosphoglycerate … Web3 de nov. de 2016 · Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL). Because no other gene is …
WebEPAS1. Endothelial PAS domain-containing protein 1 ( EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in … Web5 de out. de 2024 · Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive …
WebGN44028 是一种缺氧诱导因子 (HIF)-1的有效抑制剂，其IC50 值为 14 nM。. GN44028 能抑制低氧诱导的HIF-1α 的转录活性，但不抑制HIF-1α mRNA 的表达，HIF-1α 蛋白的累积 …
Web12 de ago. de 2010 · The HIF2α puzzle. The transcriptional regulators hypoxia-inducible factor 1α ( HIF1α) and HIF2α are overexpressed in many cancers, and it has been suggested that the HIFs could be potential ... highcharts setextremes exampleWeb5 de jun. de 2015 · We sought to establish if the observed increase in HIF2A mRNA expression in hypoxic neuroblastoma cells was a general tumor cell phenomenon. In … highcharts servicenowWeb29 de jul. de 2024 · Reinforces Important Progress in Merck’s Oncology Pipeline to Advance Novel Therapeutic Candidates Merck (NYSE: MRK), known as MSD outside the United … highcharts-serverside-exportWeb2 de ago. de 2010 · Generation of myeloid-specific HIF-2α–null mice. To characterize HIF-2α function in macrophages, we crossed the floxed Hif2a allele to LysM-Cre animals (Figure (Figure1A). 1 A). Progeny carrying the mutant genotype (Hif2a 2L/1L, LysM-Cre) were designated Hif2a Δ/Δ, whereas progeny carrying the control genotype (Hif2a 2L/+, LysM … highcharts series data arrayWeb20 de dez. de 2024 · 细胞信号通路详解之HIF1α通路. 动物细胞中，对氧气的感知和反应是一个非常重要的过程，在包括癌症、心血管疾病和中风在内的多种疾病的病理生理学中占 … how far is the moon in inchesWeb20 de jun. de 2024 · In this review, we will discuss the current understandings of hypoxia signaling in human diseases by the organ systems, including the heart, lung, liver, and … how far is the moon in feetWeb6 de out. de 2024 · HIF-2α-KO Treg cells have normal suppressive function in vitro. Next, we determined the in vitro suppressive activity of tTreg cells. Cd4 Cre Hif2a f/f tTreg cells … highcharts series data array of objects