Slow off-rate modified aptamer

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August undefined, 2024

WebbAptamers can circumvent these limitations, but their application has been hindered by nonspecific binding to cellular components, particularly in the nucleus. Here we describe … Webb20 aug. 2024 · Slow off-rate modified aptamers (SOMAmers) are introduced as small and specific labeling reagents for use with DNA points accumulation in nanoscale …

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Webb3 apr. 2024 · Protein diagnostic applications typically require pairs of analyte-specific reagents for capture and detection. We developed methods for the systematic isolation … Webb26 nov. 2011 · Slow off-rate modified aptamers (SOMAmers) are a new class of aptamer binding reagents that contain novel chemically modified nucleotides and are selected … florida dmv tag renewal website

Modified aptamers enable quantitative sub-10-nm cellular …

Webb17 apr. 2024 · Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical … Webb21 sep. 2015 · The SOMAscan™ assay is a highly multiplexed, sensitive, quantitative and reproducible proteomic tool for discovering previously undetected biomarkers for drug … florida dmv temporary plate

Slow Off-Rate Modified DNA Aptamer Inhibitors of IL -6 Signaling

Strategies to manipulate the performance of aptamers in SELEX, …

Webb27 juli 2011 · The company's mission is to use its proprietary Slow Off-rate Modified Aptamer ("SOMAmer") technology to develop enhanced protein analysis tools and … WebbWe present an on-chip electrophoretic assay for rapid protein detection with a SOMAmer (Slow Off-Rate Modified Aptamer) reagent. We used isotachophoresis (ITP) coupled with … great wall china locationWebb6 okt. 2016 · 蛋白质-核酸适配体复合物的分离方法在筛选适配体的 SELEX 过程中，高效、快速地分离与靶标结合的单链核酸是提高筛选效率的关键一步。其分离过程通常需要 … florida dmv skip the line

"Webb30 maj 2015 · The Slow Off-rate Modified Aptamers (SOMAmers) are short deoxyoligonucleotides, which bind to peptides or proteins and can be isolated in vitro. … " - Slow off-rate modified aptamer

Slow off-rate modified aptamer

WebbSlow off-rate-modified aptamers as nucleic acid analogues to antibodies have been successfully applied to improve the resolution and quantification of DNA-PAINT. In this … WebbRapid Histochemistry Using Slow Off-rate Modified Aptamers With Anionic Competition.. Applied Immunohistochemistry & Molecular Morphology. Jan 2011, 19 (1): Epub ahead of print. PMID 21217521. doi:10.1097/PAI.0b013e3182008c29.

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Webb1 maj 2024 · Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical … Webb8 feb. 2024 · SomaScan Assay profiles more than 7,000 proteins in only 55 µL of sample. The assay runs on Tecan’s Fluent liquid handling platform and utilizes a unique set of …

WebbSOMAmer (Slow Off-rate Modified Aptamer) selections [22], they find that functionalization with nonpolar moi-eties appears to promote faster selection … Webb1 mars 2024 · The aptamers selected from this base modified library are known as “SOMAmers” (Slow off-rate modified aptamers) due to the low K off rates when it is …

Webb25 sep. 2024 · We sought to determine whether slow off-rate modified aptamer (SOMAmer) reagents with subnanomolar affinity for Mycobacterium tuberculosis … WebbThe invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the SOMAmer comprises a nucleotide sequence specific for …

Webb1 sep. 2024 · Slow off-rate modified aptamer proteomics is an attractive analytical tool for rapid proteomic stratification of different malignant gliomas and identified cluster …

Webb3 sep. 2024 · Slow off-rate modified aptamer proteomics is an attractive analytical tool for rapid proteomic stratification of different malignant gliomas and identified cluster … florida dmv seminole county phone numberWebbBaird, G. S. et al. Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array. Am. J. Pathol. 180, 446–456 (2012). ... of how the systemic … great wall china marathonWebbSearch Results for Slow Off Rate Modified Aptamers on Bioz, providing objective ratings for all products used in life science research. Home > Search Results ... Rate Modified … florida dmv search by vinWebbAccurate quantification of soluble glypican-3 in clinical samples using immunoassays is challenging, because of the lack of appropriate antibody reagents to provide a full … great wall china pell cityWebb14 feb. 2024 · These unique Slow Off-rate Modified Aptamer (SOMAmer) protein affinity reagents incorporate chemically modified nucleotides that enhance the specificity and affinity of protein–nucleic acid... great wall china super buffet dinner priceWebbSomaLogic's SOMAmer - Slow Off-rate Modified Aptamer. 1/1. choose "the right target, the right compound, and the right patients" to streamline product development for other … florida dmv title address changeWebbTo expand the genetic code beyond the four natural nitrogenous bases, modified or artificial nucleobases have been introduced that allow a much more complex repertoire … great wall china longest structure